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Weight Loss & GLP-1 Protocols

GLP-1, GIP, and amylin receptor agonists for medically supervised weight management, appetite suppression, and metabolic health.

About Weight Loss & GLP-1

GLP-1 receptor agonists and related metabolic peptides represent the most clinically validated class of peptide therapies for weight management. These protocols work by modulating appetite signaling, slowing gastric emptying, and improving insulin sensitivity — producing sustained fat loss that's distinct from stimulant-based approaches.

What to expect

Most weight-loss peptide protocols involve a gradual titration phase over 4–12 weeks, starting at a low dose to minimize gastrointestinal side effects before reaching a maintenance dose. Cycle lengths typically range from 12 to 52 weeks depending on the peptide and clinical goals. Weekly subcutaneous injections are most common.

18 Protocols in this category

AOD-9604 Dosing Protocol: 10 mg Vial — Extended Fat Loss Protocol Guide

AOD-9604 10 mg vial guide — 20-day supply at 500 µg/day, ideal for extended visceral fat reduction cycles with reduced reconstitution frequency.

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AOD-9604 Dosing Protocol: 5 mg Vial — Fat Loss Peptide Dosing Guide

AOD-9604 lipolytic HGH fragment dosing guide for the 5 mg vial — subcutaneous injection protocol for targeted fat loss without IGF-1 elevation.

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Mazdutide Dosing Protocol: 10 mg Vial — Full Titration & Maintenance Guide

Complete mazdutide titration from 3 mg to 9 mg maintenance using the 10 mg compounded vial, covering the full GLORY Phase 3 dose range.

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Mazdutide Dosing Protocol: 5 mg Vial — Week-by-Week Titration & Supplies

Dosing protocol for mazdutide (IBI362, Innovent Biologics) using the 5 mg compounded vial, based on GLORY Phase 3 trial titration data.

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Survodutide Dosing Protocol: 10 mg Vial — Week-by-Week Titration & Supplies

Complete titration schedule and reconstitution guide for survodutide (BI 456906) using the 10 mg compounded vial, based on Phase 2b OASIS trial data.

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Cagrilintide Dosing Protocol: 10 mg Vial — Week-by-Week Titration & Supplies

Higher-volume cagrilintide protocol guide for the 10 mg compounded vial — ideal for patients advancing through mid-to-high dose titration.

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Cagrilintide Dosing Protocol: 5 mg Vial — Week-by-Week Titration & Supplies

Amylin analogue cagrilintide titration schedule using the 5 mg vial, based on Phase 2 CagriSema trial titration data.

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Retatrutide Dosing Protocol: 30 mg Vial — Maintenance Dosing & Supplies

Extended supply guide for the 30 mg retatrutide vial — designed for patients established on 8–12 mg maintenance dosing.

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Retatrutide Dosing Protocol: 20 mg Vial — Week-by-Week Titration & Supplies

High-concentration retatrutide protocol for patients advancing to 8–12 mg maintenance using the 20 mg compounded vial.

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Retatrutide Dosing Protocol: 10 mg Vial — Week-by-Week Titration & Supplies

Titration schedule and supplies for the 10 mg retatrutide compounded vial, covering weeks 1–12 of the standard titration.

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Retatrutide Dosing Protocol: 5 mg Vial — Week-by-Week Titration & Supplies

Complete dosing protocol for retatrutide (LY3437943) using the 5 mg compounded vial, based on Phase 2 trial titration schedules.

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Tirzepatide Dosing Protocol: 30 mg Vial — Week-by-Week Titration & Supplies

Multi-month supply guide for the 30 mg compounded tirzepatide vial — efficient high-volume reconstitution for extended cycles.

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Tirzepatide Dosing Protocol: 15 mg Vial — Week-by-Week Titration & Supplies

Full titration schedule and reconstitution guide for the high-dose 15 mg compounded tirzepatide vial (10 mg/mL).

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Tirzepatide Dosing Protocol: 10 mg Vial — Week-by-Week Titration & Supplies

Reconstitution guide, titration table, and supplies checklist for the 10 mg compounded tirzepatide vial.

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Tirzepatide Dosing Protocol: 5 mg Vial — Week-by-Week Titration & Supplies

Precise titration schedule, reconstitution steps, and supplies checklist for the 5 mg tirzepatide compounded vial.

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Semaglutide 5 mg Vial Dosing Protocol

Reconstitution guide, week-by-week titration, and supplies for a 5 mg semaglutide vial.

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Semaglutide 20 mg Vial Dosing Protocol

Reconstitution guide, week-by-week titration, and supplies for a 20 mg semaglutide vial.

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Semaglutide 10 mg Vial Dosing Protocol

Reconstitution guide, week-by-week titration, and supplies for a 10 mg semaglutide vial.

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Related peptide profiles

Learn about the peptides used in these protocols — mechanisms, research, and clinical context.

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Protocol guides are for informational purposes only and do not constitute medical advice. Dosing, cycle length, and peptide selection should be determined by a licensed healthcare provider based on your individual health profile.