PeptideClinicLocatortitle: ARA-290 lastReviewed: "2026-02" faqs:
- question: What is ARA-290 used for? answer: ARA-290 is primarily used in research settings for inflammation studies and tissue protection research.
- question: Is ARA-290 FDA-approved? answer: No, ARA-290 is not FDA-approved and is available for research purposes only.
- question: What are the side effects of ARA-290? answer: Common side effects have been reported in preclinical studies, but human data is limited.
- question: How does ARA-290 work? answer: ARA-290 binds to the EPOR–CD131 receptor complex, activating the innate repair receptor pathway without stimulating erythropoiesis.
- question: Can ARA-290 be used for treating neuropathic pain? answer: Some research suggests potential benefits for neuropathic pain, but it is not approved for clinical use.
Overview
ARA-290 is a synthetic peptide derived from the B-helix domain of erythropoietin. It has garnered interest primarily for its potential tissue-protective and anti-inflammatory properties. Researchers are exploring its use in various preclinical settings, including inflammation studies and tissue protection research. However, it is crucial to note that ARA-290 is not FDA-approved and is available exclusively for research purposes.
The peptide functions by targeting the innate repair receptor (IRR) pathway, which may offer therapeutic benefits without the erythropoietic effects typically associated with erythropoietin. Despite promising early research, ARA-290 remains a research-only compound, and its use is restricted to controlled experimental environments.
How It Works (Mechanism of Action)
ARA-290 operates by binding to the EPOR–CD131 receptor complex, which activates the innate repair receptor (IRR) pathway. This pathway is involved in tissue protection and anti-inflammatory responses. Unlike erythropoietin, ARA-290 does not stimulate erythropoiesis, making it potentially safer for therapeutic applications where erythropoiesis is undesirable. Studies, such as PMID 34343617, have highlighted its role in modulating immune functions without causing off-target effects.
