PeptideClinicLocatortitle: 5-Amino-1MQ lastReviewed: "2026-02" faqs:
- question: Is 5-Amino-1MQ approved by the FDA? answer: No, 5-Amino-1MQ is not approved by the FDA and is available for research purposes only.
- question: What is the primary mechanism of action for 5-Amino-1MQ? answer: 5-Amino-1MQ functions as a selective nicotinamide N-methyltransferase (NNMT) inhibitor, enhancing the NAD⁺ salvage pathway.
- question: What are the potential uses of 5-Amino-1MQ? answer: It is primarily used in research for epigenetic control, redox control, cellular metabolism, and aging research.
- question: What are the common side effects of 5-Amino-1MQ? answer: There is limited data on side effects as 5-Amino-1MQ is primarily studied in preclinical settings.
- question: How is 5-Amino-1MQ administered? answer: 5-Amino-1MQ is administered orally in research settings.
## Overview
5-Amino-1MQ is a small-molecule research compound that has garnered interest due to its potential applications in anti-aging and longevity research. It functions primarily as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), which plays a role in cellular metabolism. Despite its intriguing potential, 5-Amino-1MQ is not FDA-approved and is available strictly for research purposes.
Researchers are particularly interested in 5-Amino-1MQ due to its ability to enhance the NAD⁺ salvage pathway, a critical process in cellular energy metabolism and aging. However, it is crucial to note that 5-Amino-1MQ remains a research-only compound, with current studies focusing on preclinical models to explore its efficacy and safety.
## How It Works (Mechanism of Action)
5-Amino-1MQ acts by selectively inhibiting the enzyme NNMT, which is involved in the methylation of nicotinamide. This inhibition is believed to enhance the NAD⁺ salvage pathway, a key metabolic route that maintains cellular energy balance and supports healthy aging processes. The compound's mechanism of action has been explored in preclinical studies, highlighting its potential to influence metabolic and epigenetic pathways (PMID 29395804).
## Primary Uses
### Epigenetic Control
5-Amino-1MQ is studied for its potential effects on epigenetic regulation, particularly through NNMT inhibition. The evidence for this use remains at the preclinical level, primarily involving in-vitro studies and animal models.
### Redox Control
Research suggests that 5-Amino-1MQ could influence redox balance by modulating NAD⁺ levels, which are crucial for oxidative stress management. This application is still under investigation in laboratory settings.
### Cellular Metabolism and Aging Research
The compound's role in enhancing the NAD⁺ salvage pathway has made it a subject of interest in aging research. Current evidence is limited to preclinical studies, and its effects in humans have yet to be established.
## FDA & Regulatory Status
5-Amino-1MQ is not approved by the FDA for any therapeutic use. It is classified as a research compound and is available only for laboratory studies. There have been no specific enforcement actions or warnings issued by the FDA regarding this compound, but it is important to adhere to regulatory guidelines when conducting research.
## Clinical Evidence
The evidence supporting the use of 5-Amino-1MQ comes from preclinical studies, including in-vitro and animal models. No human clinical trials have been registered or conducted to date. The existing research focuses on its biochemical interactions and potential metabolic effects (PMID 9643626).
## Side Effects & Safety
As 5-Amino-1MQ is primarily studied in laboratory settings, comprehensive data on side effects in humans is lacking. Preclinical studies have not reported significant adverse effects, but the safety profile remains largely undefined. Researchers should exercise caution and conduct thorough risk assessments before use in any experimental setting.
## What to Expect at a Clinic
Given that 5-Amino-1MQ is not approved for clinical use, it is not administered in typical medical clinics. Research settings that study this compound may involve an oral administration protocol, with a focus on monitoring metabolic and biochemical parameters. Researchers should prepare to discuss the study's objectives, potential outcomes, and safety measures with their team.
## Cost & Insurance
As a research-only compound, 5-Amino-1MQ is not covered by insurance, and costs are typically borne by research institutions. It is not eligible for HSA or FSA reimbursement. Researchers should budget for procurement through specialized suppliers.
## Related Peptides
- [NAD⁺ Precursors](/peptides/nad-precursors): Explores compounds that enhance NAD⁺ levels, similar to 5-Amino-1MQ.
- [Epitalon](/peptides/epitalon): Known for its potential anti-aging effects, also studied in longevity research.
This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any treatment.
