Melanotan 2 (MT2) Dosage Guide: How Much Should You Take? (2026)

Key Takeaways

• Standard Dosage Range: Typically ranges from 0.25 mg to 1 mg per administration.
• Administration Method: Most commonly administered via subcutaneous injection.
• Typical Cycle Length: Cycles can range from a few weeks to several months depending on individual goals and response.
• Regulatory Status: Melanotan 2 is not FDA-approved and is available for research purposes only.
• Medical Supervision: Essential for safe and effective use, given the lack of FDA approval and potential side effects.

How Melanotan 2 (MT2) Works in the Body

Melanotan 2 (MT2) is a synthetic analog of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It functions as a nonselective agonist for melanocortin receptors, particularly MC1R and MC4R, which are involved in pigmentation and energy homeostasis, respectively. By binding to these receptors, MT2 stimulates melanin production, leading to skin darkening.

The pharmacokinetics of MT2 are critical in determining appropriate dosing. The peptide has a half-life of approximately 30 minutes to 1 hour, necessitating frequent administration to maintain stable plasma levels. Its bioavailability is influenced by the administration route, with subcutaneous injection providing the most efficient absorption.

"Melanotan 2's ability to induce skin pigmentation is well-documented in preclinical studies, highlighting its potential for therapeutic applications in conditions like erythropoietic protoporphyria." (PMID: 22419711)

Clinical data suggest that the efficacy and safety of MT2 depend significantly on the dosing protocol, emphasizing the importance of individualized treatment plans.

Standard Melanotan 2 (MT2) Dosage Ranges (By Form)

Subcutaneous Injection

• Dosage Range: 0.25 mg to 1 mg per injection.
• Frequency: Typically administered once daily or every other day.
• Bioavailability: High, due to direct absorption into the bloodstream.
• Commonality: The most common form due to its superior bioavailability and ease of administration.

Intramuscular Injection

• Dosage Range: Similar to subcutaneous, though slightly less common.
• Frequency: Once daily or as recommended by a healthcare provider.
• Bioavailability: Comparable to subcutaneous, though injection technique may affect absorption.

Oral and Other Forms

• Bioavailability: Limited data available, generally considered lower than injectable forms.
• Commonality: Less common due to reduced efficacy and absorption issues.

Melanotan 2 (MT2) Dosage by Use Case

Skin Pigmentation

• Typical Dosage Range: 0.5 mg to 1 mg per administration.
• Administration Method: Subcutaneous injection preferred.
• Cycle Length: Typically 4-8 weeks, adjust based on skin response.
• Clinical Reference: "Efficacy of Melanotan 2 in increasing melanin density was observed in a controlled trial." (PMID: 18047981)
• Practical Guidance: Many clinics initiate treatment with a lower dose, gradually increasing based on patient tolerance and response.

Sexual Dysfunction

• Typical Dosage Range: 0.25 mg to 0.5 mg as needed.
• Administration Method: Subcutaneous injection.
• Cycle Length: Often used acutely rather than in cycles.
• Clinical Reference: "MT2 has shown promise in improving erectile function in animal models." (PMID: 17653273)
• Practical Guidance: Administration is often timed 30-60 minutes before anticipated sexual activity.

Appetite Suppression

• Typical Dosage Range: 0.5 mg to 1 mg daily.
• Administration Method: Subcutaneous injection.
• Cycle Length: Varies; typically monitored closely for efficacy and side effects.
• Clinical Reference: "Melanotan 2's role in appetite regulation is supported by its action on MC4R." (PMID: 21746794)
• Practical Guidance: Dosage adjustments may be necessary based on individual appetite suppression response.

How Long Should You Take Melanotan 2 (MT2)?

Typical cycle lengths for MT2 can vary based on the intended outcome. For skin pigmentation, users often start seeing results within the first week, with significant changes by weeks 2-4. Cycles may last from 4 to 8 weeks, with maintenance doses administered as needed.

Tapering is generally not required, but some individuals may choose to gradually reduce the dose to minimize potential side effects. Upon discontinuation, pigmentation effects may persist for several weeks but will eventually diminish without continued use.

Administration Protocol: How to Take Melanotan 2 (MT2)

Injection Technique

• Needle Gauge: Use a 29-31 gauge insulin syringe.
• Injection Sites: Rotate between the abdomen, thigh, and upper arm to minimize local irritation.
• Rotation Schedule: Change injection sites with each administration to reduce the risk of tissue damage and ensure even absorption.

Storage and Reconstitution

• Storage Requirements: Store lyophilized powder in a cool, dry place. Once reconstituted, refrigerate and use within 30 days.
• Reconstitution Instructions: Use bacteriostatic water for reconstitution. Inject the water slowly into the vial to avoid foaming. Swirl gently to mix.

Step-by-Step Administration Process

1. Wash hands thoroughly.
2. Clean the injection site with an alcohol swab.
3. Draw the appropriate dose into the syringe.
4. Pinch the skin at the injection site and insert the needle at a 45-degree angle.
5. Inject the peptide slowly and steadily.
6. Withdraw the needle and dispose of it safely.
7. Apply gentle pressure to the injection site with a clean swab.

Stacking Melanotan 2 (MT2) for Better Results

MT2 and BPC-157

• Combination: Often used together for enhanced skin healing and pigmentation.
• Dosing Synergy: MT2 at 0.5 mg with BPC-157 at 200 mcg.
• Protocol: Administer MT2 daily and BPC-157 twice daily.
• Related Page: BPC-157

MT2 and Ipamorelin

• Combination: Used for synergistic effects on weight management and skin appearance.
• Dosing Synergy: MT2 at 0.5 mg with Ipamorelin at 100-200 mcg.
• Protocol: Administer both peptides subcutaneously, typically before bedtime.
• Related Page: Ipamorelin

Factors That Affect Your Melanotan 2 (MT2) Dosage

Individual factors such as body weight, age, and treatment goals significantly influence MT2 dosing. Providers may adjust doses for patients with impaired kidney or liver function or those taking other medications. Personal response to MT2 also varies, necessitating individualized dosing regimens.

Common Dosing Mistakes to Avoid

1. Dosing Too High/Too Low: Start with a lower dose and adjust based on response to minimize side effects.
2. Inconsistent Timing: Maintain a consistent dosing schedule to ensure stable plasma levels.
3. Wrong Injection Site: Use recommended sites to optimize absorption and minimize irritation.
4. Not Accounting for Regulatory Status: Understand that MT2 is not FDA-approved and should be used under medical supervision.
5. Poor Storage/Handling: Follow storage guidelines to preserve peptide stability and efficacy.

What the Evidence Does Not Show

While MT2 shows promise in preclinical studies, long-term safety data in humans is lacking. Most evidence is from animal studies or limited human trials, and the dose-response relationship is not fully understood. Further research is necessary to establish comprehensive safety and efficacy profiles.

FAQ — Your Top Melanotan 2 (MT2) Dosage Questions Answered

What is the best time of day to take Melanotan 2 (MT2)?

Administration is typically flexible, but some prefer evening doses to align with natural circadian rhythms and minimize daytime side effects.

What if you miss a dose?

If a dose is missed, take it as soon as you remember unless it's close to the next scheduled dose. Do not double the dose.

Can men and women use the same dose?

Yes, dosing is generally similar for men and women, but individual response may vary.

Can you stack it with other peptides?

Yes, MT2 is often stacked with peptides like BPC-157 or Ipamorelin for synergistic effects.

How long until you see results?

Initial results may be visible within the first week, with more significant effects by week 2-4.

Do you need to cycle off?

Cycling off is not necessary for all users, but some may choose to reduce dosing after achieving desired results.

Is a loading dose needed?

Some protocols include a loading dose to achieve quicker results, but this should be done under medical supervision.

How to adjust dose if side effects occur?

If side effects occur, reduce the dose or frequency and consult a healthcare provider.

Conclusion — Finding the Right Dosage for You

Determining the optimal Melanotan 2 (MT2) dosage involves understanding your specific goals, health status, and response to treatment. Medical supervision is crucial, especially given the peptide's research-only status. For more information and to find a qualified provider, visit our clinic finder and explore related peptides like BPC-157 and Ipamorelin.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Dosage information is compiled from published research and clinical protocols. Consult a licensed healthcare provider before starting any peptide therapy. Use our clinic finder to locate a qualified provider near you.