Melanotan 1 (MT1) Dosage Guide: How Much Should You Take? (2026)

Key Takeaways

• Standard Dosage Range: Melanotan 1 (MT1) typically ranges from 0.25 mg to 1 mg per administration, depending on the form and use case.
• Administration Method: Primarily administered subcutaneously; other forms are less common.
• Typical Cycle Length: Often prescribed in cycles of 4-8 weeks, with adjustments based on individual response.
• Regulatory Status: Not FDA-approved; available for research purposes only.
• Medical Supervision: Essential to ensure safety and efficacy, given the lack of FDA approval.

How Melanotan 1 (MT1) Works in the Body

Melanotan 1 (MT1) is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH), primarily used in research to study melanocortin receptor activation. Its mechanism of action involves activating cAMP-dependent signaling cascades, which play a crucial role in pigmentation and photoprotective pathways. This activation results in increased melanin production, which can influence skin pigmentation and offer potential photoprotection.

The pharmacokinetic properties of MT1, such as receptor binding affinity, half-life, and bioavailability, are critical in determining appropriate dosing. Melanotan 1 has a relatively high receptor binding affinity, which enhances its efficacy in activating melanocortin receptors. Its half-life is approximately 30 minutes, necessitating careful consideration of dosing frequency to maintain therapeutic levels. Bioavailability varies depending on the administration route, with subcutaneous injections offering more predictable absorption compared to other forms.

"Three phase 1 clinical trials of a superpotent melanotropic peptide, melanotan-1 (MT-1, or [Nle(4)-D-Phe(7)]alpha-melanocyte-stimulating hormone) were performed to demonstrate safety for MT-1 therapy combined with UV-B light or sunlight." (PMID 15262693)

"The overall objective of this research was to develop a sensitive, specific, and stability-indicating HPLC assay for the determination of the [Nle4-DPhe7]alpha-melanocyte-stimulating hormone analog known as Melanotan-1 (MT-1) in biological matrices." (PMID 8548013)

Standard Melanotan 1 (MT1) Dosage Ranges (By Form)

Subcutaneous Injection

• Dosage Range: 0.25 mg to 1 mg per injection.
• Frequency: Typically administered once daily.
• Bioavailability: High, due to direct absorption into the bloodstream.
• Commonality: Most prevalent form due to its effective delivery and absorption.

Intramuscular Injection

• Dosage Range: Similar to subcutaneous, 0.25 mg to 1 mg.
• Frequency: Once daily or every other day, depending on individual response.
• Bioavailability: Comparable to subcutaneous but less commonly used due to increased discomfort.

Oral and Other Forms

• Dosage Range: Not well-established due to low bioavailability.
• Frequency: Varies; less common due to inconsistent absorption.
• Bioavailability: Significantly lower compared to injectable forms.

The subcutaneous route remains the most common due to its ease of administration and reliable bioavailability, making it the preferred choice in research settings.

Melanotan 1 (MT1) Dosage by Use Case

Skin Pigmentation Enhancement

• Typical Dosage Range: 0.25 mg to 0.5 mg per day.
• Administration Method: Subcutaneous injection.
• Cycle Length: 4-6 weeks, with potential maintenance doses thereafter.
• Study Reference: "Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers" (PMID 15262693).
• Practical Guidance: Many clinics suggest starting at the lower end of the dosage range and adjusting based on skin response.

Photoprotection Research

• Typical Dosage Range: 0.5 mg to 1 mg per day.
• Administration Method: Subcutaneous injection.
• Cycle Length: 6-8 weeks, often aligned with periods of increased UV exposure.
• Clinical Reference: Research indicates potential benefits in photoprotection, though human trials are limited.

Receptor Pharmacology Studies

• Typical Dosage Range: Variable, tailored to specific research protocols.
• Administration Method: Often subcutaneous or intramuscular, depending on study design.
• Cycle Length: As determined by research objectives.
• Reference: Ongoing studies explore receptor activation pathways using MT1.

How Long Should You Take Melanotan 1 (MT1)?

Typical MT1 cycles range from 4 to 8 weeks, depending on the desired outcome and individual response. Initial results may be observed within the first 2-4 weeks, with more pronounced effects typically appearing by week 6. Tapering off is not usually required, but some protocols suggest maintenance doses to sustain effects.

When discontinuing MT1, any pigmentation effects will gradually diminish as melanin production returns to baseline levels. Monitoring by a healthcare provider is advised to adjust the cycle length and dosing as needed.

Administration Protocol: How to Take Melanotan 1 (MT1)

Injection Technique

• Needle Gauge: Typically 29-31 gauge for subcutaneous injections.
• Injection Sites: Abdomen, thighs, or upper arms. Rotate sites to minimize irritation.
• Rotation Schedule: Alternate sites daily to prevent tissue damage.

Storage and Reconstitution

• Storage Requirements: Store lyophilized powder in a refrigerator at 2-8°C. Reconstituted solution should be used within 30 days.
• Reconstitution Instructions: Dilute with bacteriostatic water according to specific concentration requirements. Link to reconstitution guide.

Step-by-Step Administration

1. Wash Hands: Ensure hands are clean to prevent contamination.
2. Prepare Injection: Draw the reconstituted solution into a syringe.
3. Select Site: Choose an appropriate injection site and clean with an alcohol swab.
4. Administer Injection: Insert the needle at a 45-degree angle for subcutaneous injections.
5. Dispose of Materials: Safely dispose of the needle and syringe in a sharps container.

Stacking Melanotan 1 (MT1) for Better Results

Melanotan 1 (MT1) and Bremelanotide

• Combination: Used to explore synergistic effects on melanocortin receptors.
• Dosing Synergy: MT1 at 0.5 mg with Bremelanotide at 1.25 mg.
• Protocol Use: Investigated for enhanced pigmentation and potential sexual health benefits.

Melanotan 1 (MT1) and CJC-1295

• Combination: Explored for combined effects on skin health and anti-aging.
• Dosing Synergy: MT1 at 0.5 mg with CJC-1295 at 2 mg per week.
• Protocol Use: Common in anti-aging research protocols.

Factors That Affect Your Melanotan 1 (MT1) Dosage

Several factors can influence the appropriate dosage of MT1, including body weight, age, treatment goals, and individual response. Providers may adjust dosing based on these variables to optimize outcomes and minimize side effects. Understanding these factors is crucial, as a one-size-fits-all approach is not effective.

Common Dosing Mistakes to Avoid

1. Dosing Too High/Too Low: Start with a conservative dose and adjust based on response.
2. Inconsistent Timing: Administer at the same time each day to maintain stable levels.
3. Wrong Injection Site: Use appropriate sites and rotate to avoid tissue damage.
4. Not Accounting for Regulatory Status: Use MT1 responsibly, acknowledging its research-only status.
5. Poor Storage/Handling: Follow storage guidelines to maintain peptide integrity.

What the Evidence Does Not Show

While MT1 shows promise in pigmentation and photoprotection research, there are significant gaps in long-term safety data and human trials. Current evidence is largely preclinical, and more robust clinical trials are needed to establish definitive therapeutic protocols and safety profiles.

FAQ — Your Top Melanotan 1 (MT1) Dosage Questions Answered

Best time of day to take it?

MT1 is typically administered in the evening to align with natural circadian rhythms and minimize potential side effects.

What if you miss a dose?

If you miss a dose, take it as soon as you remember unless it's close to the time of your next dose. Do not double up.

Can men and women use the same dose?

Yes, dosing is generally similar for men and women, but individual responses may vary.

Can you stack it with other peptides?

Yes, MT1 is often stacked with peptides like Bremelanotide or CJC-1295 for enhanced effects.

How long until you see results?

Initial results may be visible within 2-4 weeks, with more pronounced effects by week 6.

Do you need to cycle off?

Cycling off is not mandatory, but maintenance doses may be used to sustain effects.

Is a loading dose needed?

Some protocols include a loading phase to quickly achieve desired pigmentation levels.

How to adjust dose if side effects occur?

If side effects occur, reduce the dose and consult with a healthcare provider.

Conclusion — Finding the Right Dosage for You

Determining the right Melanotan 1 (MT1) dosage involves considering several factors, including individual response and treatment goals. Given its research-only status, medical supervision is crucial to ensure safety and efficacy. For more information, explore our clinic finder and related peptide resources on PeptideClinicLocator.com.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Dosage information is compiled from published research and clinical protocols. Consult a licensed healthcare provider before starting any peptide therapy. Use our clinic finder to locate a qualified provider near you.