AOD-9604 + MOTS-c Fat Loss Stack: Does It Work? (2026)

Key Takeaways

• The Fat Loss Peptide Stack combines AOD-9604 and MOTS-c to target metabolic pathways for fat reduction.
• AOD-9604 is a growth hormone fragment, while MOTS-c is a mitochondrial-derived peptide; both are used in metabolic research.
• The typical duration for this stack is 8 weeks, with specific dosing protocols for each peptide.
• Both peptides are not FDA-approved and are available for research purposes only.
• Legal use in clinics is restricted due to their classification as Category 2 substances.

What Is the Fat Loss Peptide Stack (AOD-9604 + MOTS-c)?

The Fat Loss Peptide Stack, featuring AOD-9604 and MOTS-c, is designed to synergistically target fat loss through metabolic modulation. This protocol has gained popularity among those exploring advanced peptide therapies for weight management and metabolic enhancement.

AOD-9604

AOD-9604 is a modified fragment of human growth hormone (hGH fragment 176-191) that focuses on lipid metabolism without the growth-promoting effects associated with full-length growth hormone. Its mechanism involves modulating lipid and glucose metabolism pathways through β-adrenergic and AMPK-related mechanisms (PMID 15134286).

MOTS-c

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids, involved in cellular metabolism. It enhances glucose metabolism and is believed to mimic some effects of exercise by influencing nuclear gene expression during metabolic stress (PMID 36761202).

Regulatory Status: Both AOD-9604 and MOTS-c are classified as research-only substances, not FDA-approved for clinical use. They are available for research purposes under strict regulatory conditions.

How the Fat Loss Peptide Stack (AOD-9604 + MOTS-c) Works

The combination of AOD-9604 and MOTS-c aims to enhance metabolic processes, potentially leading to fat loss.

Individual Mechanisms

• AOD-9604: Acts on lipid metabolism, potentially increasing fat breakdown while sparing muscle mass (PMID 24124033).
• MOTS-c: Influences cellular energy balance and enhances glucose uptake in muscle tissues, acting as a metabolic regulator (PMID 34798268).

Synergistic Effects

Together, these peptides may complement each other by targeting different aspects of metabolism. AOD-9604 focuses on lipid breakdown, while MOTS-c enhances overall metabolic efficiency, potentially leading to improved body composition.

Fat Loss Peptide Stack (AOD-9604 + MOTS-c) Dosing Protocol

The dosing protocol for this peptide stack is crucial for achieving desired outcomes while minimizing risks.

| Peptide | Dose | Administration | Timing | Cycle Length | |---------|------|----------------|--------|--------------| | AOD-9604 | 250-500 mcg daily | Subcutaneous | Morning | 8 weeks | | MOTS-c | 5-10 mg 2-3x weekly | Subcutaneous | Post-exercise | 8 weeks |

Sources:

• Clinical research and published dosing protocols (PMID 15134286, PMID 36761202).

Administration Guide

Administering the peptides correctly is vital for effectiveness and safety.

• Mixing: Do not mix peptides in the same syringe.
• Injection Timing: AOD-9604 is best administered in the morning, while MOTS-c should be injected post-exercise.
• Reconstitution: Use bacteriostatic water for reconstitution. Follow specific guidelines for each peptide.
• Storage: Store reconstituted peptides in the refrigerator and use within 28 days.
• Equipment: Use a 29-31 gauge insulin syringe for subcutaneous injections.

Who Is This Protocol For?

This protocol may be suitable for individuals with specific goals:

Athletes Recovering from Injury

The stack may help manage body composition during recovery periods without compromising muscle mass.

Post-Surgical Recovery

Patients seeking to manage weight post-surgery might find this stack beneficial due to its metabolic effects.

Anti-Aging / Longevity Goals

Those focusing on metabolic health as part of an anti-aging strategy may consider this stack for its potential to enhance energy metabolism.

Expected Results and Timeline

Week 1-2

• Initial metabolic adjustments; some users report increased energy levels.

Week 3-4

• Enhanced fat metabolism; noticeable changes in body composition for some users.

Week 5-8

• Full effects on metabolism and body composition may be observed; continued fat loss.

Post-Cycle

• Maintenance of results depends on lifestyle factors such as diet and exercise.

Potential Side Effects and Risks

Understanding the risks involved with this protocol is crucial.

Common Side Effects

• AOD-9604: Headache, nausea, localized injection site reactions.
• MOTS-c: Possible gastrointestinal disturbances, fatigue.

Contraindications and Interactions

• Not recommended for individuals with active cancer or severe metabolic disorders.
• Potential interactions with medications affecting metabolic pathways.

Medical Supervision

Regular monitoring by a healthcare provider is advised, including periodic bloodwork to assess metabolic markers.

Legal and Regulatory Status

Both AOD-9604 and MOTS-c are not FDA-approved and are classified as Category 2 substances, meaning they are prohibited for compounding in the US. They are available only for research use, and clinics must adhere to strict regulatory guidelines.

Alternative Protocols

For those seeking legal options, consider FDA-approved peptides or medications:

• Semaglutide: A GLP-1 agonist with strong evidence for weight management.
• Tirzepatide: Another GLP-1 agonist with proven efficacy in clinical trials.

What the Evidence Does Not Show

• No human studies have conclusively demonstrated the efficacy of this peptide stack for fat loss.
• Current evidence is based on individual peptide studies, not the combination.

FAQ

How long should I run this protocol?

Typically, the protocol is run for 8 weeks.

Can I modify the doses?

Dose modifications should only be done under medical supervision due to potential risks.

Is this protocol legal?

Both peptides are for research use only and not approved for clinical use.

Do I need a prescription?

Yes, a prescription is required for legal research use in the US.

Can women use this protocol?

Yes, but it should be under medical supervision, considering potential hormonal interactions.

What bloodwork should I get?

Regular monitoring of metabolic markers, including glucose and lipid panels, is recommended.

Where can I find a clinic that offers this?

Use our clinic finder to locate clinics offering peptide therapies.

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any treatment.