PeptideClinicLocatortitle: KPV (Ac-KPV-NH2) lastReviewed: "2026-02" faqs:
- question: What is KPV (Ac-KPV-NH2)? answer: KPV is a synthetic tripeptide fragment derived from alpha-melanocyte-stimulating hormone (α-MSH) and is used primarily in research for its potential effects on inflammation and immune responses.
- question: Is KPV FDA-approved? answer: No, KPV is not FDA-approved and is available for research purposes only.
- question: How does KPV work? answer: KPV modulates inflammatory signaling by activating melanocortin receptors and influencing the NF-κB pathway.
- question: What are the side effects of KPV? answer: The side effects of KPV are not well-documented in humans as it is primarily studied in preclinical settings.
- question: Can KPV be covered by insurance? answer: Since KPV is not FDA-approved and is for research use only, it is not typically covered by insurance.
Overview
KPV (Ac-KPV-NH2) is a synthetic tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). Researchers are interested in KPV due to its potential roles in modulating immune responses and maintaining epithelial integrity. Currently, KPV is classified as a research-only peptide and is not approved by the FDA for clinical use. This means it is primarily available for investigational purposes and not for therapeutic applications in humans.
Despite its limited regulatory status, KPV has garnered attention for its potential in influencing cytokine balance and addressing immune-mediated stress responses. However, it is crucial for practitioners and patients to recognize that any use outside of a research setting is not sanctioned by regulatory authorities and should be approached with caution.
How It Works (Mechanism of Action)
KPV exerts its effects through the activation of melanocortin receptors, which are involved in regulating inflammatory processes. It also modulates the NF-κB pathway, a critical signaling cascade in immune responses and inflammation. These actions suggest that KPV may play a role in maintaining epithelial integrity and modulating immune responses, although these effects are primarily observed in preclinical studies (PMID 29953505).
