How Much Does PE-22-28 Cost in 2026? Pricing Breakdown

Key Takeaways

• PE-22-28 is not FDA-approved and is available only for research purposes, making it difficult to obtain legally for therapeutic use.
• Costs for research-grade PE-22-28 typically range from $100 to $300 per 10 mg vial.
• Insurance does not cover PE-22-28, as it is not approved for clinical use.
• Telehealth platforms may offer bundled pricing for consultations and similar peptides.
• Cost-reduction options are limited due to its research-only status, but discounts on research-grade materials may be available.

What Is PE-22-28?

PE-22-28 is a research peptide derived from the C-terminal fragment of pituitary adenylyl cyclase-activating polypeptide (PACAP 1–38). It modulates neuropeptide signaling through PAC1 receptor activation, influencing synaptic plasticity and neuroprotection. For more details, visit the full profile.

Typical Cost Ranges

Given its status as a research peptide, PE-22-28 is not legally available for therapeutic use in the United States. The peptide can be obtained for research purposes, with prices typically ranging from $100 to $300 per 10 mg vial. These prices reflect the cost of research-grade materials, which are not intended for human use. Due to its non-therapeutic status, there is no brand-name or compounded medication available legally, and cost information for therapeutic use is not applicable.

Insurance Coverage

As PE-22-28 is not FDA-approved for any medical indication, it is not covered by insurance plans. FDA-approved peptides may have some insurance coverage, but research-only peptides like PE-22-28 are generally not eligible. Patients interested in similar peptides that are FDA-approved should consult their insurers for coverage specifics, including prior authorization and step therapy requirements.

HSA/FSA Eligibility

PE-22-28 does not qualify for Health Savings Account (HSA) or Flexible Spending Account (FSA) spending, as it is not approved for medical use. Typically, only FDA-approved medications are eligible for HSA/FSA reimbursement.

Telehealth vs. In-Person Pricing

Telehealth platforms often offer bundled pricing for consultations and medications, which may include peptides similar to PE-22-28. These bundles can provide cost savings compared to traditional in-person clinic visits. However, since PE-22-28 is not legally available for therapeutic use, telehealth services cannot offer it as part of their programs.

Ways to Reduce Cost

Cost-reduction options for PE-22-28 are limited due to its research-only status. However, some research suppliers may offer discounts or bulk purchase options for laboratories. Patients seeking similar therapeutic peptides should inquire about manufacturer savings programs, patient assistance programs, and discount tools like GoodRx for approved medications.

Cost Compared to Alternatives

For patients exploring neuroprotective peptides, alternatives such as Cerebrolysin and Semax may be considered. Cerebrolysin, for instance, is available in some countries for neuroprotection and may cost approximately $15 to $30 per ampoule. Semax is another alternative, with prices around $20 to $40 per vial, depending on the supplier and location.

What to Ask Your Provider About Cost

When discussing peptide therapy costs with your healthcare provider, consider asking:

• Are there FDA-approved alternatives to PE-22-28 that might be covered by insurance?
• What are the expected costs for consultations and follow-up visits?
• Are there any patient assistance programs available for similar peptides?

FAQ

Is PE-22-28 available for purchase in the US?

No, PE-22-28 is not legally available for therapeutic use in the United States. It is only available for research purposes.

Can I use insurance to cover the cost of PE-22-28?

Insurance does not cover PE-22-28, as it is not FDA-approved for any medical indication.

Are there any legal alternatives to PE-22-28?

Yes, alternatives such as Cerebrolysin and Semax are available for neuroprotection, depending on regional regulations and approvals.

How can I reduce the cost of similar peptide therapies?

Consider exploring manufacturer savings programs, patient assistance programs, and discount tools for FDA-approved peptides.

Do telehealth services offer PE-22-28?

Telehealth services cannot legally offer PE-22-28 for therapeutic use, but they may provide similar peptides as part of their programs.

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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any treatment.